Sepsis has been recently defined as the ‘life-threatening organ dysfunction caused by a dysregulated host response to infection’. This definition represents a clinical syndrome associated with an increased risk of death from an invading pathogen. Within it falls the impact of a broad range of organisms, sites of infection and host responses. The sepsis syndrome is associated with a huge healthcare, social and economic burden, which results in the loss of an estimated 5.3 million lives world-wide every year.
The sepsis syndrome results in the loss of an estimated 5.3 million lives world-wide every year
Many of the mechanisms that underlie the development, progression and outcomes from sepsis remain unresolved. This may in part explain the failure to develop new therapeutic agents for the treatment of our patients during the last 30 years.
Our goal is to bridge the gap between basic science and clinical practice, to translate mechanistic insights from the laboratory into robust human studies. The group brings together different approaches to understanding the host response to infection through its work exploring the mechanisms of vascular dysfunction in sepsis, the development of nosocomial infection and the regulation of the innate immune response.