University Lecturer and Consultant Anaesthetist
Prof Jon Coles is a Cambridge University Lecturer. He qualified at Leicester University and trained in Anaesthesia and Intensive Care Medicine in Leicester, Norwich and Cambridge.
As a clinician specialising within Neurointensive care and Neuroanaesthesia his research interests are focused on describing the pathophysiology of various forms of brain injury and optimising patient outcome.
Using the combined facilities of the Wolfson Brain Imaging Centre and Neurosciences Critical Care Unit at Addenbrooke’s Hospital patients undergo structural and functional imaging studies using positron emission tomography and magnetic resonance imaging.
He has used such imaging tools to define the incidence, temporal evolution and impact on outcome of cerebral ischaemia following head injury.
He has quantified the impact of clinical interventions aimed at controlling intracranial pressure such as hyperventilation and elevation of cerebral perfusion pressure.
His current studies are aimed at describing the mechanisms and temporal pattern of neuronal loss following head injury. Such knowledge could lead to changes in patient care, and hopefully better functional outcomes for patients.