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Research

Division of Anaesthesia

Department of Medicine

Publications

Sections:

Acute brain injury

  • Exploring New Routes for Neuroprotective Drug Development in Traumatic Brain Injury. Janowitz T, Menon DK. Science Translational Medicine. 2010;2:27-37. [PubMed][Full text]
  • Hierarchical log linear analysis of admission blood parameters and clinical outcome following traumatic brain injury. Helmy A, Timofeev I, Palmer CR, Gore A, Menon DK, Hutchinson PJ. Acta Neurochirurgica (Wien). 2010 Jan 13. [PubMed]
  • Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat. Hughes JL, Beech JS, Jones PS, Wang D, Menon DK, Baron JC. Neuroimage. 2009;49(1):19-31. [PubMed]
  • Prediction of outcome in severe traumatic brain injury. Menon DK, Zahed C. Current Opinion in Critical Care. 2009;15(5):437-41. [PubMed]
  • The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study. Gallagher CN, Carpenter KL, Grice P, Howe DJ, Mason A, Timofeev I, Menon DK, Kirkpatrick PJ, Pickard JD, Sutherland GR, Hutchinson PJ. Brain. 2009;132(Pt 10):2839-49. [PubMed]
  • Low-dose and high-dose synacthen tests and the hemodynamic response to hydrocortisone in acute traumatic brain injury. Wijesurendra RS, Bernard F, Outtrim J, Maiya B, Joshi S, Hutchinson PJ, Halsall DJ, Menon DK. Neurocritical Care. 2009;11(2):158-64. [PubMed]
  • Early metabolic characteristics of lesion and nonlesion tissue after head injury. Coles JP, Cunningham AS, Salvador R, Chatfield DA, Carpenter A, Pickard JD, Menon DK. Journal of Cerebral Blood Flow and Metabolism. 2009;29(5):965-75. [PubMed]
  • Molecular mechanisms of traumatic brain injury: the missing link in management. Veenith T, Goon SSh, Burnstein RM. World Journal of Emergency Surgery. 2009;4:7. [PubMed]
  • The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury. Zygun DA, Nortje J, Hutchinson PJ, Timofeev I, Menon DK, Gupta AK. Critical Care Medicine. 2009;37(3):1074-8. [PubMed]
  • Unique challenges in clinical trials in traumatic brain injury. Menon DK. Critical Care Medicine. 2009;37(1 Suppl):S129-35. [PubMed]
  • A combined microdialysis and FDG-PET study of glucose metabolism in head injury. Hutchinson PJ, O’Connell MT, Seal A, Nortje J, Timofeev I, Al-Rawi PG, Coles JP, Fryer TD, Menon DK, Pickard JD, Carpenter KL. Acta Neurochirurgica (Wien). 2009;151(1):51-61; discussion 61. [PubMed]
  • Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure. Geeraerts T, Newcombe VF, Coles JP, Abate MG, Perkes IE, Hutchinson PJ, Outtrim JG, Chatfield DA, Menon DK. Crit Care. 2008;12(5):R114. [PubMed]
  • Potential heating caused by intraparenchymal intracranial pressure transducers in a 3-tesla magnetic resonance imaging system using a body radiofrequency resonator: assessment of the Codman MicroSensor Transducer. Newcombe VF, Hawkes RC, Harding SG, Willcox R, Brock S, Hutchinson PJ, Menon DK, Carpenter TA, Coles JP. Journal of Neurosurgery. 2008;109(1):159-64. [PubMed]
  • Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity. Abate MG, Trivedi M, Fryer TD, Smielewski P, Chatfield DA, Williams GB, Aigbirhio F, Carpenter TA, Pickard JD, Menon DK, Coles JP. Neurocritical Care. 2008;9(3):319-25. [PubMed]
  • Serum albumin level as a predictor of outcome in traumatic brain injury: potential for treatment. Bernard F, Al-Tamimi YZ, Chatfield D, Lynch AG, Matta BF, Menon DK. Journal of Trauma. 2008;64(4):872-5. [PubMed]
  • Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma. Newcombe VF, Williams GB, Nortje J, Bradley PG, Chatfield DA, Outtrim JG, Harding SG, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK. Acta Neurochirurgica Supplement. 2008;102:247-51. [PubMed]
  • Nitric oxide in acute brain injury: a pilot study of NO(x) concentrations in human brain microdialysates and their relationship with energy metabolism. Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD, Hutchinson PJ. Acta Neurochirurgica Supplement. 2008;102:207-13.  [PubMed]
  • Ventriculostomy for control of raised ICP in acute traumatic brain injury. Timofeev I, Dahyot-Fizelier C, Keong N, Nortje J, Al-Rawi PG, Czosnyka M, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ. Acta Neurochirurgica Supplement. 2008;102:99-104. [PubMed]
  • Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings. Nortje J, Coles JP, Timofeev I, Fryer TD, Aigbirhio FI, Smielewski P, Outtrim JG, Chatfield DA, Pickard JD, Hutchinson PJ, Gupta AK, Menon DK. Critical Care Medicine. 2008;36(1):273-81. Journal of Neurotrauma. 2007;24(10):1545-57. [PubMed]
  • Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. Hutchinson PJ, O’Connell MT, Rothwell NJ, Hopkins SJ, Nortje J, Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD. Journal of Neurotrauma. 2007;24(10):1545-57. [PubMed]
  • Analysis of acute traumatic axonal injury using diffusion tensor imaging. Newcombe VF, Williams GB, Nortje J, Bradley PG, Harding SG, Smielewski P, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK. British Journal of Neurosurgery. 2007;21(4):340-8. [PubMed]
  • Case mix, outcomes and comparison of risk prediction models for admissions to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC Case Mix Programme Database. Hyam JA, Welch CA, Harrison DA, Menon DK. Critical Care. 2006;10 Suppl 2:S2. [PubMed]
  • Deferred consent in emergency intensive care research: what if the patient dies early? Use the data or not? Jansen TC, Kompanje EJ, Druml C, Menon DK, Wiedermann CJ, Bakker Journal of Intensive Care Medicine. 2007;33(5):894-900. [PubMed]
  • Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo. Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P, Menon DK, Caldwell MA. Experimental Neurology. 2007;204(2):512-24. [PubMed]
  • Microdialysis in the management of hepatic encephalopathy. Hutchinson PJ, Gimson A, Al-Rawi PG, O’Connell MT, Czosnyka M, Menon DK. Neurocrit Care. 2006;5(3):202-5. [PubMed]
  • Hemodynamic steroid responsiveness is predictive of neurological outcome after traumatic brain injury. Bernard F, Outtrim J, Lynch AG, Menon DK, Matta BF. Neurocritical Care. 2006;5(3):176-9. [PubMed]
  • The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro. Beech JS, Wheeler DW, Reckless J, Grant AJ, Price J, Mastroeni P, Grainger DJ, Menon DK. Journal of Neuroimmunology. 2007;184(1-2):198-208. [PubMed]
  • Mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome. Mannion RJ, Cross J, Bradley P, Coles JP, Chatfield D, Carpenter A, Pickard JD, Menon DK, Hutchinson PJ. Journal of Neurotrauma. 2007;24(1):128-35. [PubMed]
  • Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism. Coles JP, Fryer TD, Coleman MR, Smielewski P, Gupta AK, Minhas PS, Aigbirhio F, Chatfield DA, Williams GB, Boniface S, Carpenter TA, Clark JC, Pickard JD, Menon DK. Critical Care Medicine. 2007;35(2):568-78. [PubMed]
  • Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study. Takasawa M, Beech JS, Fryer TD, Hong YT, Hughes JL, Igase K, Jones PS, Smith R, Aigbirhio FI, Menon DK, Clark JC, Baron JC. Journal of Cerebral Blood Flow and Metabolism. 2007;27(4):679-89. [PubMed]
  • Cognitive reserve as a resilience factor against depression after moderate/severe head injury. Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ. Journal of Neurotrauma. 2006;23(7):1049-58. [PubMed]
  • Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke. Price CJ, Wang D, Menon DK, Guadagno JV, Cleij M, Fryer T, Aigbirhio F, Baron JC, Warburton EA. Stroke. 2006;37(7):1749-53. [PubMed]
  • Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study. Hutchinson PJ, Corteen E, Czosnyka M, Mendelow AD, Menon DK, Mitchell P, Murray G, Pickard JD, Rickels E, Sahuquillo J, Servadei F, Teasdale GM, Timofeev I, Unterberg A, Kirkpatrick PJ. Acta Neurochir Suppl. 2006;96:17-20. [PubMed]
  • Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy. Timofeev I, Kirkpatrick PJ, Corteen E, Hiler M, Czosnyka M, Menon DK, Pickard JD, Hutchinson PJ. Acta Neurochirurgica Supplement. 2006;96:11-6. [PubMed]
  • Changes over time in cognitive and structural profiles of head injury survivors. Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ. Neuropsychologia. 2006;44(10):1995-8. [PubMed]
  • Brain ischaemia after traumatic brain injury: lessons from 15O2 positron emission tomography. Menon DK. Current Opinion in Critical Care. 2006;12(2):85-9. [PubMed]
  • An investigation of auto-reactivity after head injury. Cox AL, Coles AJ, Nortje J, Bradley PG, Chatfield DA, Thompson SJ, Menon DK. J Neuroimmunol. 2006 May;174(1-2):180-6. [PubMed]
  • Corticosteroids after traumatic brain injury: new evidence to support their use. Bernard F, Menon DK, Matta BF. Critical Care Medicine. 2006;34(2):583. [PubMed]
  • Incidence of adrenal insufficiency after severe traumatic brain injury varies according to definition used: clinical implications. Bernard F, Outtrim J, Menon DK, Matta BF. British Journal of Anaesthesia. 2006;96(1):72-6. [PubMed]
  • Diffusion tensor imaging in chronic head injury survivors: correlations with learning and memory indices. Salmond CH, Menon DK, Chatfield DA, Williams GB, Pena A, Sahakian BJ, Pickard JD. Neuroimage. 2006;29(1):117-24. [PubMed]
  • Intersubject variability and reproducibility of 15O PET studies. Coles JP, Fryer TD, Bradley PG, Nortje J, Smielewski P, Rice K, Clark JC, Pickard JD, Menon DK. Journal of Cerebral Blood Flow and Metabolism. 2006;26(1):48-57. [PubMed]
  • Imaging of cerebral blood flow and metabolism in brain injury in the ICU. Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK. Acta Neurochirurgica Supplement. 2005;95:459-64. [PubMed]
  • Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study. O’Connell MT, Seal A, Nortje J, Al-Rawi PG, Coles JP, Fryer TD, Menon DK, Pickard JD, Hutchinson PJ. Acta Neurochir Suppl. 2005;95:165-8. [PubMed]
  • Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury. Steiner LA, Balestreri M, Johnston AJ, Coles JP, Chatfield DA, Pickard JD, Menon DK, Czosnyka M. Acta Neurochir Suppl. 2005;95:17-20. [PubMed]
  • Effect of methylene blue on middle cerebral artery flow velocity in a patient with severe sepsis following clipping of a cerebral aneurysm. Zygun DA, Bradley PG, Menon DK. Neurocritical Care. 2005;2(1):39-42. [PubMed]
  • Metallic neurosurgical implants for cranial reconstruction and fixation: assessment of magnetic field interactions, heating and artefacts at 3.0 Tesla. Cunningham AS, Harding S, Chatfield DA, Hutchinson P, Carpenter TA, Pickard JD, Menon DK. British Journal of Neurosurgery. 2005;19(2):167-72. [PubMed]
  • Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury. Cunningham AS, Salvador R, Coles JP, Chatfield DA, Bradley PG, Johnston AJ, Steiner LA, Fryer TD, Aigbirhio FI, Smielewski P, Williams GB, Carpenter TA, Gillard JH, Pickard JD, Menon DK. Brain. 2005;128(Pt 8):1931-42. [PubMed]
  • Cerebral microdialysis methodology–evaluation of 20 kDa and 100 kDa catheters. Hutchinson PJ, O’Connell MT, Nortje J, Smith P, Al-Rawi PG, Gupta AK, Menon DK, Pickard JD. Physiological Measurement. 2005;26(4):423-8. [PubMed]
  • Predicting the response of intracranial pressure to moderate hyperventilation. Steiner LA, Balestreri M, Johnston AJ, Coles JP, Smielewski P, Pickard JD, Menon DK, Czosnyka M. Acta Neurochirurgica (Wien). 2005;147(5):477-83. [PubMed]
  • Neuroprotection (including hypothermia). Menon DK, Summors AC. Current Opinion in Anaesthesiology. 1998;11(5):485-96. [PubMed]
  • Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury. Johnston AJ, Steiner LA, Coles JP, Chatfield DA, Fryer TD, Smielewski P, Hutchinson PJ, O’Connell MT, Al-Rawi PG, Aigbirihio FI, Clark JC, Pickard JD, Gupta AK, Menon DK. Critical Care Medicine. 2005;33(1):189-95. [PubMed]
  • Decompressive craniectomy in traumatic brain injury–time for randomised trials? Hutchinson PJ, Menon DK, Kirkpatrick PJ. Acta Neurochirurgica (Wien). 2005;147(1):1-3. [PubMed]
  • Formal characterization and extension of the linearized diffusion tensor model. Salvador R, Peña A, Menon DK, Carpenter TA, Pickard JD, Bullmore ET. Human Brain Mapping. 2005;24(2):144-55. [PubMed]
  • Evaluation of infusion pump performance in a magnetic resonance environment. Bradley PG, Harding SG, Reape-Moore K, Abeygunaratne R, Menon DK. European Journal of Anaesthesiology. 2004;21(9):729-33. [PubMed]
  • Traumatic brain injury: physiology, mechanisms, and outcome. Nortje J, Menon DK. Current Opinion in Neurology. 2004;17(6):711-8. [PubMed]
  • Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure. Steiner LA, Balestreri M, Johnston AJ, Czosnyka M, Coles JP, Chatfield DA, Smielewski P, Pickard JD, Menon DK. Intensive Care Medicine. 2004;30(12):2180-7. [PubMed]
  • Hyperglycemia and brain tissue pH after traumatic brain injury. Zygun DA, Steiner LA, Johnston AJ, Hutchinson PJ, Al-Rawi PG, Chatfield D, Kirkpatrick PJ, Menon DK, Gupta AK. Neurosurgery. 2004;55(4):877-81. [PubMed]
  • Does induced hypertension reduce cerebral ischaemia within the traumatized human brain? Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smieleweski P, Chatfield DA, Aigbirhio F, Williams GB, Boniface S, Rice K, Clark JC, Pickard JD, Menon DK. Brain. 2004;127(Pt 11):2479-90. [PubMed]
  • Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury. Gupta AK, Zygun DA, Johnston AJ, Steiner LA, Al-Rawi PG, Chatfield D, Shepherd E, Kirkpatrick PJ, Hutchinson PJ, Menon DK. Journal of Neurotrauma. 2004;21(6):678-84. [PubMed]
  • Diffusion limited oxygen delivery following head injury. Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD. Critical Care Medicine. 2004;32(6):1384-90. [PubMed]
  • Cerebral neutrophil recruitment, histology, and outcome in acute ischemic stroke: an imaging-based study. Price CJ, Menon DK, Peters AM, Ballinger JR, Barber RW, Balan KK, Lynch A, Xuereb JH, Fryer T, Guadagno JV, Warburton EA. Stroke. 2004 Jul;35(7):1659-64. [PubMed]
  • Terlipressin for cerebral perfusion pressure support in a patient with septic shock. Bradley PG, Allen EK, Menon DK. Anaesthesia. 2004;59(6):619-20. [PubMed]
  • Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients. Steiner LA, Johnston AJ, Czosnyka M, Chatfield DA, Salvador R, Coles JP, Gupta AK, Pickard JD, Menon DK. Critical Care Medicine. 2004;32(4):1049-54. [PubMed]
  • Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury. Johnston AJ, Steiner LA, Chatfield DA, Coles JP, Hutchinson PJ, Al-Rawi PG, Menon DK, Gupta AK. Intensive Care Medicine. 2004;30(5):791-7. [PubMed]
  • Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson’s disease. Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA. International Journal of Biochemistry & Cell Biology. 2004;36(4):702-13. [PubMed]
  • Incidence and mechanisms of cerebral ischemia in early clinical head injury. Coles JP, Fryer TD, Smielewski P, Chatfield DA, Steiner LA, Johnston AJ, Downey SP, Williams GB, Aigbirhio F, Hutchinson PJ, Rice K, Carpenter TA, Clark JC, Pickard JD, Menon DK. Journal of Cerebral Blood Flow and Metabolism. 2004;24(2):202-11. [PubMed]
  • Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology. Coles JP, Fryer TD, Smielewski P, Rice K, Clark JC, Pickard JD, Menon DK. Journal of Cerebral Blood Flow and Metabolism. 2004;24(2):191-201. [PubMed]
  • Comparative tolerability of sedative agents in head-injured adults. Urwin SC, Menon DK. Drug Safety. 2004;27(2):107-33. [PubMed]
  • Non-neurological organ dysfunction in neurocritical care. Zygun DA, Doig CJ, Gupta AK, Whiting G, Nicholas C, Shepherd E, Conway-Smith C, Menon DK. Journal of Critical Care. 2003;18(4):238-44. [PubMed]
  • Integrated image analysis solutions for PET datasets in damaged brain. Smielewski P, Coles JP, Fryer TD, Minhas PS, Menon DK, Pickard JD. Journal of Clinical Monitoring and Computing. 2002;17(7-8):427-40. [PubMed]
  • Effects of propofol on cerebral oxygenation and metabolism after head injury. Johnston AJ, Steiner LA, Chatfield DA, Coleman MR, Coles JP, Al-Rawi PG, Menon DK, Gupta AK. British Journal of Anaesthesia. 2003;91(6):781-6. [PubMed]
  • Human cellular inflammation in the pathology of acute cerebral ischaemia. Price CJ, Warburton EA, Menon DK. Journal of Neurology, Neurosurgery and Psychiatry. 2003;74(11):1476-84. [PubMed]
  • Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure. Steiner LA, Coles JP, Johnston AJ, Czosnyka M, Fryer TD, Smielewski P, Chatfield DA, Salvador R, Aigbirhio FI, Clark JC, Menon DK, Pickard JD. Journal of Cerebral Blood Flow and Metabolism. 2003;23(11):1371-7.  [PubMed]
  • Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients. Johnston AJ, Steiner LA, O’Connell M, Chatfield DA, Gupta AK, Menon DK. Intensive Care Medicine. 2004;30(1):45-50. [PubMed]
  • Cost-effective outcome for treating poor-grade subarachnoid hemorrhage. Wilby MJ, Sharp M, Whitfield PC, Hutchinson PJ, Menon DK, Kirkpatrick PJ. Stroke. 2003;34(10):2508-11. [PubMed]
  • Assessment of cerebrovascular autoregulation in head-injured patients: a validation study. Steiner LA, Coles JP, Johnston AJ, Chatfield DA, Smielewski P, Fryer TD, Aigbirhio FI, Clark JC, Pickard JD, Menon DK, Czosnyka M. Stroke. 2003 Oct;34(10):2404-9. [PubMed]
  • Images in clinical medicine. Carotid-artery thrombosis secondary to basal skull fracture. Santarius T, Menon DK. New England Journal of Medicine. 2003;31;349(5):e5. [PubMed]
  • The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients. Steiner LA, Johnston AJ, Chatfield DA, Czosnyka M, Coleman MR, Coles JP, Gupta AK, Pickard JD, Menon DK. Anesthesia and Analgesia. 2003;97(2):572-6. [PubMed]
  • Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity. Johnston AJ, Steiner LA, Gupta AK, Menon DK. British Journal of Anaesthesia. 2003;90(6):774-86. [PubMed]
  • Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury. Steiner LA, Coles JP, Czosnyka M, Minhas PS, Fryer TD, Aigbirhio FI, Clark JC, Smielewski P, Chatfield DA, Donovan T, Pickard JD, Menon DK. Journal of Neurology, Neurosurgery and Psychiatry. 2003;74(6):765-70. [PubMed]
  • Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage. Minhas PS, Menon DK, Smielewski P, Czosnyka M, Kirkpatrick PJ, Clark JC, Pickard JD. Neurosurgery. 2003;52(5):1017-22; discussion 1022-4.  [PubMed]
  • Hyperoxia and the cerebral hemodynamic responses to moderate hyperventilation. Johnston AJ, Steiner LA, Balestreri M, Gupta AK, Menon DK. Acta Anaesthesiologica Scandinavica. 2003;47(4):391-6. [PubMed]
  • Validation of a tonometric noninvasive arterial blood pressure monitor in the intensive care setting. Steiner LA, Johnston AJ, Salvador R, Czosnyka M, Menon DK. Anaesthesia. 2003;58(5):448-54. [PubMed]
  • Procrustes, the traumatic penumbra, and perfusion pressure targets in closed head injury. Menon DK. Anesthesiology. 2003 Apr;98(4):805-7. [PubMed]
  • Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner. Coles JP, Steiner LA, Martin J, Donovan T, Hutchinson PJ, Carpenter TA, Menon DK. Anaesthesia. 2003;58(2):143-8. [PubMed]
  • Discordant temporal patterns of S100beta and cleaved tau protein elevation after head injury: a pilot study. Chatfield DA, Zemlan FP, Day DJ, Menon DK. British Journal of Neurosurgery. 2002;16(5):471-6. [PubMed]
  • Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates. Coles JP, Minhas PS, Fryer TD, Smielewski P, Aigbirihio F, Donovan T, Downey SP, Williams G, Chatfield D, Matthews JC, Gupta AK, Carpenter TA, Clark JC, Pickard JD, Menon DK. Critical Care Medicine. 2002;30(9):1950-9. [PubMed]
  • Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study. Hutchinson PJ, Gupta AK, Fryer TF, Al-Rawi PG, Chatfield DA, Coles JP, O’Connell MT, Kett-White R, Minhas PS, Aigbirhio FI, Clark JC, Kirkpatrick PJ, Menon DK, Pickard JD. Journal of Cerebral Blood Flow and Metabolism. 2002;22(6):735-45. [PubMed]
  • Specialist neurocritical care and outcome from head injury. Patel HC, Menon DK, Tebbs S, Hawker R, Hutchinson PJ, Kirkpatrick PJ. Intensive Care Medicine. 2002;28(5):547-53. [PubMed]
  • Assessment of the Caradyne WhisperFlow for administration of continuous positive airway pressure in a 3 Tesla magnetic resonance scanner. Steiner LA, Chatfield DA, Donovan T, Coles JP, Menon DK. Anaesthesia. 2002;57(5):470-4. [PubMed]
  • Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury. Steiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD. Critical Care Medicine. 2002;30(4):733-8. [PubMed]
  • Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent. Hutchinson PJ, O’Connell MT, Coles JP, Chatfield DA, Coleman MR, Al-Rawi PG, Kett-White CR, Gupta AK, Menon DK, Boniface SJ, Heazell M, Kirkpatrick PJ, Pickard JD. British Journal of Clinical Pharmacology. 2002;53(3):275-83. [PubMed]
  • Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method. Gupta AK, Hutchinson PJ, Fryer T, Al-Rawi PG, Parry DA, Minhas PS, Kett-White R, Kirkpatrick PJ, Mathews JC, Downey S, Aigbirhio F, Clark J, Pickard JD, Menon DK. Journal of Neurosurgery. 2002;96(2):263-8. [PubMed]
  • Serum S100 protein as a marker of cerebral damage during cardiac surgery. Kuzumi E, Vuylsteke A, Guo X, Menon DK. British Journal of Anaesthesia. 2000;85(6):936-7. [PubMed]
  • Neuroprotection in ischemia-reperfusion injury: an antiinflammatory approach using a novel broad-spectrum chemokine inhibitor. Beech JS, Reckless J, Mosedale DE, Grainger DJ, Williams SC, Menon DK. Journal of Cerebral Blood Flow and Metabolism. 2001;21(6):683-9. [PubMed]
  • Propofol use in head-injury patients. Menon DK, Matta BF, Gupta AK, Swami A. Lancet. 2001;357(9269):1708-9. [PubMed]
  • Management of comatose head-injured patients: are we getting any better? Wilkins IA, Menon DK, Matta BF. Anaesthesia. 2001;56(4):350-2. [PubMed]

Physiology in Critical Illness

  • Nosocomial H1N1 infection during 2010-2011 pandemic: a retrospective cohort study from a tertiary referral hospital. Veenith T, Sanfilippo F, Ercole A, Carter E, Goldman N, Bradley PG, Gunning K, Burnstein RM. Journal of Hospital Infection 2012;81(3):202-205. [PubMed]
  • A[H1N1] flu and refractory hypoxaemia: Is extracorporial lung support the holy grail? Veenith TV, Rana M, Ercole A, Gunning K, Mahroof R. Thorax 2011;66:836-837. [PubMed]
  • Modelling the impact of pandemic influenza A(H1N1) on UK paediatric intensive care demand. Ercole A, Menon DK, O’Donnell R. Archives of Disease in Childhood 2009;94(12):962-4. [PubMed]
  • Modelling the impact of an influenza A/H1N1 pandemic on critical care demand from early pathogenicity data: the case for sentinel reporting. Ercole A, Taylor BL, Rhodes A, Menon DK. Anaesthesia. 2009;64(9):937-941. [PubMed]
  • Room air dilution of heliox given by facemask. Standley TDA, Smith HL, Brennan LJ, Wilkins IA, Bradley PG, Groba CB, Davey AJ, Menon DK, Wheeler DW. Intensive Care Medicine 2008;34:1469-1476. [PubMed]
  • Attenuation in invasive blood pressure measurement systems. Ercole A. British Journal of Anaesthesia 2006;96(5):560-2. [PubMed]
  • Modelling the impact of an influenza pandemic on critical care services in England. Menon DK, Taylor BL, Ridley SA. Anaesthesia. 2005;60(10):952-954. [PubMed]

Pain

  • When the brain expects pain: Common neural responses to pain anticipation are related to clinical pain and distress in fibromyalgia and osteoarthritis. Brown CA, El-Deredy W, Jones AKP. European Journal of Neuroscience 2014: 39(4):663-72. [PubMed]
  • Imaging opioid analgesia in the human brain and its potential relevance for understanding opioid use in chronic pain. Lee MC, Wanigasekera V, Tracey I. Neuropharmacology 2013: doi: 10.1016/j.neuropharm.2013.06.035 [PubMed]
  • Imaging pain: a potent means for investigating pain mechanisms in patients. Lee MC, Tracey I. British Journal of Anaesthesia 2013: 111(1): 64-72. [PubMed]
  • Neurogenetics of persistent pain. Lee M, Tracey I. Current Opinion in Neurobiology 2013: 23(1): 127-32
  • Amygdala activity contributes to the dissociative effects of cannabis on pain perception in humans. Lee MC, Menon DK, Ploner M, Bingel U, Weich K, Brooks J, Wanigasekera V, Tracey I. Pain 2013: 154(1): 124-34 [PubMed]
  • Baseline reward circuitry activity and trait reward responsiveness predicts expression of opioid analgesia in healthy subjects. Wanigasekera V, Lee MC, Rogers R, Kong Y, Leknes S, Andersson J, Tracey I. Proceedings of the National Academy of Sciences 2013: 23; 109(43): 17705-10 [PubMed]
  • Experimental Placebo Analgesia Changes Resting-State Alpha Oscillations. Huneke NTM, Brown CA, Burford E, Watson A, Trujillo-Barreto NJ, Jones AKP. PLoS ONE 2013, 8(10): e78278. [PubMed]
  • Psychobiological correlates of improved mental health in patients with musculoskeletal pain after a mindfulness-based pain management program. Brown CA, Jones AKP. Clinical Journal of Pain 2013. 29(3):233-244. [PubMed]
  • Relief as a reward: hedonic and neural responses to safety from pain. Leknes S, Lee M, Berna C, Andersson J, Tracey I. PLoS One 2013: 7; 6(4): e17870 [PubMed]
  • How does EEG Contribute to Our Understanding of the Placebo Response? Insights from the Perspective of Bayesian Inference. Jones AKP, Brown CA, El-Deredy W. In: Colloca L, ed. Placebo and Pain: From Bench to Bedside, Elsevier 2013, 37-
  • Stimulus site and modality dependence of functional activity within the human spinal cord. Brooks J, Kong Y, Lee M, Warnaby C, Wanigasekera V, Jenkinson M, Tracey I. Journal of Neuroscience 2012: 32(18): 6231-9 [PubMed]
  • Mindfulness meditation-related pain relief: Evidence for unique brain mechanisms in the regulation of pain. Zeidan F, Grant JA, Brown CA, McHaffie JG, Coghill RC. Neurosci Lett. 2012, 520(2):165-73. [PubMed]
  • Neural correlates of an injury-free model of central sensitization induced by opioid withdrawal in humans. Wanigasekera V, Lee MC, Rogers R, Hu P, Tracey I. Journal of Neuroscience 2011: 23; 31(8): 2835-42 [PubMed]
  • The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, Tracey I. Science Translational Medicine 2011: 16; 3(70): 70ra14 [PubMed]
  • Role of central neurophysiological systems in placebo analgesia and their relationship to cognitive processing mediating placebo responding. Brown CA, Watson A, Morton D, Power A, El-Deredy W, Jones AKP. Future Neurology. 2011, 6(3):389-398.
  • Flexible connectivity patterns subserve contextual modulation of pain. Ploner M, Lee MC, Wiech K, Bingel U, Tracey I. Cerebral Cortex 2010: 21(3): 719-26 [PubMed]
  • Prestimulus functional connectivity determines pain perception in humans. Ploner M, Lee MC, Wiech K, Bingel U, Tracey I Proceedings of the National Academy of Sciences USA 2010;107:355-360.  [PubMed]
  • Unravelling the mystery of pain, suffering and relief with brain imaging. Lee MC, Tracey I  Current Pain and Headache Reports 2010;14:124-31. [PubMed]
  • Meditation experience predicts less negative appraisal of pain: electrophysiological evidence for the involvement of anticipatory neural responses. Brown CA and Jones AKP. Pain 2010, 150(3): 428-3
  • Cognitive changes as a result of a single exposure to placebo. Morton DL, Brown CA, Watson A, El-Deredy W, and Jones AKP. Neuropsychologia 2010, 48(7): 1958-1964. [PubMed]
  • Characterizing the cortical activity through which pain emerges from nociception. Lee MC, Mouraux A, Iannetti GD. Journal of Neuroscience 2009;20:7909-7916. [PubMed]
  • Identifying brain activity specifically related to the maintenance and perceptual consequence of central sensitization in humans. Lee MC, Zambreanu L, Menon DK, Tracey I.  Journal of Neuroscience. 2008;28:11642-9. [PubMed]
  • Dissociating nociceptive modulation by the duration of pain anticipation from unpredictability in the timing of pain. Clark JA, Brown CA, Jones AKP, El-Deredy W. Clinical Neurophysiology 2008, 119: 2870-2878. [PubMed]
  • A role for midcingulate cortex in the interruptive effects of pain anticipation on attention. Brown CA and Jones AKP. Clinical Neurophysiology 2008, 119: 2370-2379 [PubMed]
  • Confidence in beliefs about pain predicts expectancy effects on pain perception and anticipatory processing in right anterior insula. Brown CA, Seymour B, El-Deredy W, Jones AKP. Pain 2008, 139(2): 324-332. [PubMed]
  • Modulation of pain ratings by expectation and uncertainty: behavioral characteristics and anticipatory neural correlates. Brown CA, Seymour B, Boyle Y, El-Deredy W, Jones AKP. Pain 2008; 135(3); 240-250 [PubMed]
  • Lidocaine intranasal spray for treatment of trigeminal neuralgia. Wheeler DW. British Journal of Anaesthesia. 2007;98(2):275. [PubMed]

Consciousness and Cognition

  • Restructuring of functional connectivity in motor network after traumatic brain injury (TBI). Kasahara M, Menon D, Salmond C, Outtrim J, Taylor Tavares J, Carpenter T, Sahakian B, Stamatakis E. Neuroimage 2009;47:S1.
  • Neural correlates of impaired performance in a working memory task in survivors of traumatic brain injury. Kasahara M, Menon D, Salmond C, Outtrim J, Taylor Tavares J, Carpenter T, Sahakian B, Stamatakis E. Journal of Neurotrauma 2009;26:A-68.
  • BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil. Absalom AR, Menon DK. Critical Care. 2009;13(2):137. [PubMed]
  • Phenytoin toxicity masquerading as motor neurone disease. Veenith T, Jellema K, Pearce A, Goon S, Burnstein R. Anaesthesia. 2009;64(3):337.  [PubMed]
  • Dissociating speech perception and comprehension at reduced levels of awareness. Davis MH, Coleman MR, Absalom AR, Rodd JM, Johnsrude IS, Matta BF, Owen AM, Menon DK. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(41):16032-7. [PubMed]
  • Do vegetative patients retain aspects of language comprehension? Evidence from fMRI. Coleman MR, Rodd JM, Davis MH, Johnsrude IS, Menon DK, Pickard JD, Owen AM. Brain. 2007;130(Pt 10):2494-507. [PubMed]
  • Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers. Absalom AR, Lee M, Menon DK, Sharar SR, De Smet T, Halliday J, Ogden M, Corlett P, Honey GD, Fletcher PC. British Journal of Anaesthesia. 2007;98(5):615-23. [PubMed]
  • Impulsivity, reward sensitivity, and decision-making in subarachnoid hemorrhage survivors. Salmond CH, DeVito EE, Clark L, Menon DK, Chatfield DA, Pickard JD, Kirkpatrick PJ, Sahakian BJ. Journal of the International Neuropsychological Society. 2006;12(5):697-706. [PubMed]
  • Attitudes of anaesthetists to awareness and depth of anaesthesia monitoring in the UK. Lau K, Matta B, Menon DK, Absalom AR. European Journal of Anaesthesiology. 2006;23(11):921-30. [PubMed]
  • Residual auditory function in persistent vegetative state: a combined PET and fMRI study. Owen AM, Coleman MR, Menon DK, Johnsrude IS, Rodd JM, Davis MH, Taylor K, Pickard JD. Neuropsychological Rehabilitation. 2005;15(3-4):290-306.  [PubMed]
  • Using a hierarchical approach to investigate residual auditory cognition in persistent vegetative state. Owen AM, Coleman MR, Menon DK, Berry EL, Johnsrude IS, Rodd JM, Davis MH, Pickard JD. Progress in Brain Research. 2005;150:457-71. [PubMed]
  • Lack of effects of guanfacine on executive and memory functions in healthy male volunteers. Müller U, Clark L, Lam ML, Moore RM, Murphy CL, Richmond NK, Sandhu RS, Wilkins IA, Menon DK, Sahakian BJ, Robbins TW. Psychopharmacology (Berlin). 2005;182(2):205-13. [PubMed]
  • Sublingual drug delivery during functional magnetic resonance imaging. Lee MC, Menon DK. Anaesthesia. 2005;60(8):821-2.  [PubMed]
  • Deficits in decision-making in head injury survivors. Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ. Journal of Neurotrauma. 2005;22(6):613-22. [PubMed]
  • Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings. Coleman MR, Menon DK, Fryer TD, Pickard JD. J Neurol Neurosurg Psychiatry. 2005;76(3):432-4. [PubMed]
  • Cognitive sequelae of head injury: involvement of basal forebrain and associated structures. Salmond CH, Chatfield DA, Menon DK, Pickard JD, Sahakian BJ. Brain. 2005;128(Pt 1):189-200. [PubMed]
  • Ketamine disrupts frontal and hippocampal contribution to encoding and retrieval of episodic memory: an fMRI study. Honey GD, Honey RA, O’Loughlin C, Sharar SR, Kumaran D, Suckling J, Menon DK, Sleator C, Bullmore ET, Fletcher PC. Cerebral Cortex. 2005;15(6):749-59. [PubMed]
  • Acute ketamine administration alters the brain responses to executive demands in a verbal working memory task: an FMRI study. Honey RA, Honey GD, O’Loughlin C, Sharar SR, Kumaran D, Bullmore ET, Menon DK, Donovan T, Lupson VC, Bisbrown-Chippendale R, Fletcher PC. Neuropsychopharmacology. 2004 Jun;29(6):1203-14. [PubMed]
  • Detecting residual cognitive function in persistent vegetative state. Owen AM, Menon DK, Johnsrude IS, Bor D, Scott SK, Manly T, Williams EJ, Mummery C, Pickard JD. Neurocase. 2002;8(5):394-403. [PubMed]
  • Mapping the anatomy of unconsciousness–imaging anaesthetic action in the brain. Menon DK. British Journal of Anaesthesia. 2001;86(5):607-10. [PubMed]

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