Position(s)

NIHR Clinical Lecturer in Intensive Care Medicine

Honorary Consultant in Anaesthesia and Intensive Care

Qualifications

MBBS | PhD | FRCA| FFICM

Biography

Simon completed his undergraduate training at Guy’s, King’s and St Thomas’ School of Medicine, and began his training in anaesthesia and intensive care in south London, before undertaking an Academic Clinical Fellowship in the north central London School of Anaesthesia.  He completed his PhD at Imperial College, London during which he explored the role of regulators of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine, in sepsis.  Simon joined the University of Cambridge in 2016 to undertake an NIHR Academic Clinical Lecturer post to complete his clinical training and develop his research programme.

Current projects

• The endogenous regulation of vascular endothelial nitric oxide production in sepsis.
• Developing new therapies for sepsis
• Early phase clinical trials in sepsis

Key words: nitric oxide, nitric oxide synthase, sepsis, endothelium, inflammation

Publications: see Critical Care Group Publications

Fitzpatrick SF, Lambden S, Macias D, Puthucheary Z, Pietsch S, Mendil L, McPhail MJW, Johnson RS. 2-Hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia. Front Physio 2020; 11:147

Zöllner J, Lambden S, Nasri NM, Johnson M, Leiper J. Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Improves the Outcome of Sepsis in Pregnant Mice. Shock 2019, in press.

Lambden S. Bench to bedside review: therapeutic modulation of nitric oxide in sepsis-an update. Intensive Care Med Exp 2019; 7:64

Lambden S, Laterre PF, Levy MM, Francois B. The SOFA score – development, utility and challenges of accurate assessment in clinical trials. Crit Care 2019; 23:374

Del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, Nightingale TD, Lambden S, Grant SGN, Gourine AV, Ackland GL. NMDA receptor modulation of glutamate release in activated neutrophils. EBioMedicine 2019, 47:457-469.

Lambden S, Tomlinson J, Piper S, Gordon AC, Leiper J. Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity. Crit Care. 2018;22:336.

Lambden S, Creagh-Brown BC, Hunt J, Summers C, Forni LG. Definitions and pathophysiology of vasoplegic shock. Crit Care. 2018; 22:174.

Lambden S, Martin D, Vanezis K, Lee B, Tomlinson J, Piper S,  Boruc O, Mythen M, Leiper J.  Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in Dimethylarginine Dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.  Nitric Oxide. 2016; 58:59-66

Kirkman MA, Lambden S, Smith M.  Challenges in the anesthetic and intensive care management of acute ischemic stroke.  J Neurosurg Anesthesiol. 2016;28:214–232

Lambden S, Kelly P, Wang Z, Ahmetaj B, Nandi M, Torondel B, Delahaye M, Dowsett L, Tomlinson J, Caplin B, Boruc O, Slaviero A, Khadayate S, Lee B, Leiper J.  Dimethylarginine Dimethylaminohydrolase 2 regulates Nitric Oxide production, haemodynamics and vascular responsiveness under basal conditions and outcome in polymicrobial sepsis. Arterioscler Thromb Vasc Biol. 2015; 35:1382-1392

Wang Z, Lambden S, Taylor V, Sujkovic E, Nandi M, Tomlinson J, Dyson A, McDonald N, Caddick S,  Singer M, Leiper J. Pharmacological inhibition of DDAH1 improves survival, hemodynamics and organ function in experimental septic shock.  Biochem J. 2014; 460:309-316

Lambden S, De Munter C, Gautama S, Cooper M, Sevdalis N.  The Imperial Paediatric Emergency Training Toolkit (IPETT) for use in paediatric emergency training: Development and evaluation of feasibility and validity. Resuscitation. 2013;  84:831-836

Walker S, Sevdalis N, McKay A, Lambden S, Gautama S, Vincent C. Unannounced In Situ Simulations: Integrating Training and Clinical Practice. BMJ Qual Safe. 2013; 22:453-458

Lambden S, Martin B. The use of Computers for perioperative simulation in anesthesia, critical care and pain medicine.  Anesthesiol Clin. 2011; 29:521-531

Walker S, Brett S, McKay A, Lambden S, Vincent C, Sevdalis N. Observational Skill-based Clinical Assessment tool for Resuscitation (OSCAR): Development and validation. Resuscitation. 2011; 82:835-44.

Lambden S, Tunnicliffe G. Clinical skills training offers sustained benefits over experiential learning alone in foundation trainees. Int J of Clinical Skills. 2010; 4:78-86

Lambden S, Akeru J, Barrett N. Acute intravascular haemolysis secondary to meropenem administration in a 64 year old man. Can J Clin Pharmacol. 2010; 17:64-66

Howsam G, Sharma A, Lambden S, Prinsley P. Bilateral objective tinnitus secondary to middle ear Myoclonus. J Laryngol Otol. 2005; 119:489-91

Vele L, Pool A, Lambden S, Long O. Trainee Development and Educational Supervision. Training Professionals – a novel way of working; RCoA Bulletin 86. 2014

Book Chapters

Lambden SPF and Summers C. Biomarkers in critical illness: ARDS and sepsis. In Precision in pulmonary, critical care and sleep medicine. Eds: Gomez JL, Himes BE, Kaminski N. Springer International Publishing, New York, 2020.

Lambden S and Summers C. Bridging the translational gap – the challenges of novel drug development in critical care.  In: Annual Update in Intensive Care and Emergency Medicine. In Press.  Springer (Heidelberg, Germany)

Snapshot of Simon’s work