Position(s)

Consultant in Anaesthesia and Intensive Care Medicine

Postdoctoral Fellow, Carroll Lab, CRUK Cambridge Institute

Qualifications

MA (Cantab) | MBChB | PhD | MRCP | FRCA

Biography

Alasdair studied medicine in Cambridge and Edinburgh, and then began his training in anaesthesia and critical care medicine in Exeter. He returned to Edinburgh to undertake his PhD jointly at the Roslin Institute and the MRC Human Genetics Unit, studying the genomic effects of glucocorticoids on macrophages.  Alasdair came to Cambridge in 2015 from a Clinical Lecturer post at the University of Edinburgh. He has joined the Carroll group at the CRUK Cambridge Institute to further his study of how nuclear hormone receptors and their ligands bring about both acute and long-term genomic changes.

Current projects

• Quantifying chromatin reorganisation and genomic responses in human monocytes in response to glucocorticoids.

Keywords: stress, glucocorticoid, chromatin, enhancer, macrophage, monocyte

Publications: see Critical Care Group Publications

Jubb A, Boyle S. Visualizing genome reorganisation using 3D DNA FISH. Methods Mol Biol 2020, 2148:85-95

Jubb AW, Hofer TP, Hime DA, Ziegler-Heitbrock L. The preterm labor associated ADAMTS2 gene is induced by glucocorticoids. Am J Obstet Gynecol. 2018; 219:122-123.

Jubb AW, Boyle S, Hume DA, Bickmore WA. Glucocorticoid receptor binding induces rapid and prolonged large-scale chromatin decompaction at multiple loci. Cell Rep 2017; 21:3022-3031.

Jubb AW, Young RS, Hume DA, Bickmore WA. Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages. J Immunol. 2016 Jan 15;196(2):813-22

Din JN, Aftab SM, Jubb AW, Carnegy FH, Lyall K, Sarma J, Newby DE, Flapan AD. Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans. Eur J Clin Nutr. 2011 Feb;65(2):234-9

Din JN, Ashman OA, Aftab SM, Jubb AW, Newby DE, Flapan AD. Increased arterial stiffness in healthy young South Asian men. J Hum Hypertens. 2006; 20(2): 163-5