This week a new report has been published in Intensive Care Medicine which describes how
cell surface markers can predict the clinical course of patients presenting to the Emergency
Department with infection. Working with colleagues at Kings College London, Newcastle
University and the University of Edinburgh, Andrew Conway Morris of the Critical Care
Biology group has demonstrated that markers of immune suppression (neutrophil CD279,
neutrophil CD24 and monocyte HLA-DR) predict subsequent deterioration into sepsis, and
could also identify patients who were rapidly discharged from hospital. This data adds
further evidence of the utility of markers of immune suppression in infection, with a
previous study from this group (Conway Morris et al, Intensive Care Medicine 2018;44:627-
635) showing that similar markers predicted a complicated course in patients admitted to
Intensive Care.
http://icmjournal.esicm.org/journals/abstract.html?v=0&j=134&i=0&a=5389_10.1007_s001 34-018-5389-0&doi=
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