Reader in Intensive Care Medicine, University of Cambridge
Co-Lead of the Perioperative, Acute, Critical Care and Emergency Medicine (PACE) Section, Department of Medicine
Deputy Director of Clinical Academic Training and Director of Academic Clinical Fellow Programme, University of Cambridge School of Clinical Medicine
Honorary Consultant in Intensive Care Medicine, Cambridge University Hospitals NHS Foundation Trust
BSc (Hons) | BM | PhD | FRCP | FFICM
Charlotte graduated in both Biomedical Sciences and Medicine from the University of Southampton, and later undertook a PhD at the University of Cambridge investigating the role of inflammation on the pulmonary transit kinetics of human neutrophils, alongside specialist clinical training in Respiratory (East of England) and Intensive Care Medicine (London). She was subsequently appointed as the UK’s first NIHR Clinical Lecturer in Intensive Care Medicine, and went on to be awarded a Fulbright All-disciplines Scholar Award and a Wellcome Trust Fellowship for Postdoctoral Clinician Scientists. Charlotte joined the University of Cambridge School of Clinical Medicine in 2015 from University of California, San Francisco.
- Elucidating the host defence mechanisms via which the pulmonary microcirculation prevents innate immune cell-mediated damage, and developing understanding of how those mechanisms fail in acute respiratory distress syndrome.
- Investigating the influence of the pulmonary microenvironment on neutrophil phenotype and function
- Determining the cellular mechanisms of acute pulmonary inflammation to help identify novel targets for therapeutic intervention
- Chief Investigator of HEAL-COVID, an NIHR funded “Urgent Public Health clinical trial of national importance”
Keywords: neutrophils, endothelium, pulmonary, respiratory failure, mechanical ventilation, physiology
For details of the Summers group’s respiratory medicine focussed research please see here
Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Head Fourman M, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Wu Y, Porteous DJ, Hayward C, Knight J,Summers C, et al. Genetic mechanisms of critical illness in COVID-19.Nature, 2021, in press.
Saha R, Assouline B, Mason G, Douiri A, Summers C, Shankar-Hari M. The impact of differences in ARDS RCT inclusion and exclusion criteria – systematic review and meta-analysis. Brit J Anaesth, 2021, in press.
Dushianthan A, Cumpstey AF, Ferrari M, Thomas W, Moonesinghe R, Summers C, Montgomery H, Grocott MPW. Intensive care physicians’ perceptions of the diagnosis and management of patients with acute hypoxic respiratory failure associated with COVID-19: a UK based survey. JICS, 2021, in press
Thwaites RS, A Sanchez SUA, Siggins MK, Liew F, Russell CD et al. Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19. Sci Immunol 2021; 6:eabg9873
Bos LDJ, Artigas A, Constantin J-M, Hagens L, Heijnen N, Laffey JG, Meyer N, Papazian L, Pisani L, Schultz MJ, Shankar-Hari M, Smit MR, Summers C, Ware LB, Scala R, Calfee C. Precision medicine in acute respiratory distress syndrome: Workshop Report and recommendations for future research. Eur Resp Rev, 2021, 30:200317
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S et al. SARS-CoV-2 evolution during treatment of chronic infection. Nature 2021, in press.
Menk M, Estenssoro E, Serpa Neto A, Sinha P, Slutsky AS, Summers C, Yoshida T, Bein T, Fergusson ND. Current and evolving standards of care for patients with ARDS. Inten Care Med 2020; 46:2157-2167.
Tong A, Baumgart A, Evangelidis N, Viecelli AK, Carter SA et al. Core outcome measures for trials in people with Coronoavirus Disese 2019: Respiratory failure, multiorgan failure, shortness of breath and recovery. Crit Care Med 2021; 49:503-16
Gupta RK, Harrison EM, Ho A, Docherty AB, Knight SR et al. Development and validation of the ISARIC4C deterioration model for adults hospitalised with COVID-19: a prospective cohort study. Lancet Respir Med 2020, in press.
Li W, Long L, Yang X, Tong Z, Southwood M, King, R, Caruso P, Upton PD, Yang P, Bocobo GA, Nikolic I, Higuera A, Salmon RM, Jiang H, Lodge KM, Hoenderdos K, Baron RM, Yu PB, Condliffe AM, Summers C, Nourshargh S, Chilvers ER, Morrell NW. Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice. Am J Respir Crit Care Med, 2020, in press.
Drake TM, Docherty AB, Harrison EM, Quint JK, Adamali H, et al. Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study. Am J Respir Crit Care Med 2020; 202:1656-1665
Bashant KR, Aponte AM, Randazzo D, Sangsari PR, Wood AJT, Bibby JA, West EE, Vassallo A, Manna Z, PlayfordMP, Jordan N, Hasni S, Gucek M, Kemper C, Conway Morris A, Morgan NY, Toepfner N, Guck J, Mehta NN, Chilvers ER, Summers C, Kaplan M. Proteomic, biomechanical, and functional analyses define neutrophil heterogeneity in systemic lupus erythematosus. Annals Rhem Dis, 2020, in press.
Kwizera A, Nakibuuka J, Nakiyingi L, Sendagire C, Tumukunde J, Katabira C, Ssenyonga R, Kiwanuka N, Kateete D, Joloba M, Kabatoro D, Atwine S, Summers C. Acute hypoxemic respiratory failure in a low-income country: a prospective observational study of hospital prevalence and mortality. BMJ Open Resp Res, 2020; 7:e000719.
Farahi N, Gillet D, Southwood M, Rassl DM, Tregay N, Uta H, Sreston SD, Loutsios C, Lok LSC, Heard S, Buscombe J, Rintoul RC, Peters AM, Summers C*, Chilvers ER*. Novel method to quantify neutrophil uptake in early lung cancer using SPECT/CT. (* joint senior authors). Thorax, 2020; 75:1020-1023.
Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y et al. Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: The REMAP-CAP COVID-19 corticosteroid domain randomised controlled trial. JAMA 2020; 324:1317-1329.
Thompson CP, Grayson NE, Paton RS, Bolton JS, Lourenço J, et al. Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. Euro Surveill 2020; 25:2000685
Knight SR, Ho A, Pius R, Buchan I, Carson G, et al. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.BMJ 2020; 370:m3339.
Swann OV, Holden KA, Turtle L, Pollock L, Fairfield CJ, et al. Clinical characteristics of children and young people admitted to hospital with COVID-19 in United Kingdom: prospective multicentre observational cohort study. BMJ 2020; 370:m3249
Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, et al. Features of 20,133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ 2020; 369:m1985
Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC. Therapeutic blockade of granulocyte macrophage-colony stimulating factor (GM-CSF) in COVID-19-associated hyperinflammation: opportunities and challenges. Lancet Respir Med, 2020;8:822-830.
Ryan J, Bayliffe AI, McAuley DF, Yeung J, Thickett DR, Howells PA, O’Donnell C, Vassallo AM, Wright TJ, McKie E, Hardes K, Summers C, et al. A randomised, placebo-controlled pilot study of a nebulised anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody in patients at risk of post-operative lung injury. Eur J Anaesthesiol 2020; 37:1014-1024.
Wood AJT, Vassallo AM, Ruchaud-Sparagano M-H, Scott J, Zinnato C, Gonzalez-Tejedo C, Kishore K, D’Santos CS, Simpson AJ, Menon DK, Summers C, Chilvers ER, Okkenhaug K, Conway Morris A. C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling. JCI Insight, 2020, in press.
Wilkinson T, Dixon R, Page C, Carroll M, Griffiths G, Ho L-P, De Soyza A, Felton T, Lewis KE, Phekoo K, Chalmers JD, Gordon A, McGarvey L, Doherty J, Read RC, Shankar-Hari M, Martinez-Alier N, O’Kelly M, Duncan G, Walles R, Sykes J, Summers C, Singh D. ACCORD: A multicentre, seamless, phase 2 adaptive randomisation platform study to assess the efficacy and safety of multiple candidate agents for the treatment of COVID-19 in hospitalised patients: A structured summary of a study protocol for a randomised controlled trial. Trials, 2020; 21:691.
Le S, Pelligrini E, Green-Saxena A, Summers C, Hoffman J, Calvert J, Das R. Supervised machine learning for the early prediction of acute respiratory distress syndrome (ARDS). J Crit Care, 2020; 60:96-102.
Bidulka P, Iwagami M, Mansfiled KE, Kalogirou F, Wong A, Douglas IJ, Smeeth L, Summers C, Tomlinson LA. Comparisons of Staphylococcus aureus infection and other outcomes between users of angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers: lessons for COVID-19 from a nationwide cohort study. Wellcome Open Research, 2020, 5:77.
Pillay J, Tregay N, Juzenaite G, Pirillo C, Gaboriau D, Farahi N, Summers C, Lo Celso C, Carlin L, Chilvers E, Rankin S, De Filippo K. Effect of CXCR4 antagonist plerixafor on endogenous neutrophil dynamics in the bone marrow, lung and spleen. J Leuk Biol, 2020; 107:1175-1185.
Bashant K, Toepfner N, Day CJ, Mehta NN, Kaplan MJ, Summers C, Guck J, Chilvers ER. The mechanics of myeloid cells. Biol Cell, 2020; 112:103-112.
Burzynski LC, Humphry M, Pyrillou K, Wiggins KA, Chan JNE, Figg N, Kitt LL, Summers C, Tatham KC, Martin PB, Bennett MR, Clarke MCH. The coagulation and immune systems are directly linked through the activation of interleukin-1-alpha by thrombin. Immunity 2019; 50:1033-1042.
Hildalgo A, Chilvers ER, Summers C, Koenderman L. The neutrophil life cycle. Trends Immunol 2019; 40:584-597.
Summers C. Chasing the ‘Holy Grail’ – modulating neutrophils in inflammatory lung disease. Am J Respir Crit Care Med2019; 200:131-132.
Bashant KR, Vassallo A, Herold C, Berner R, Menschner L, Subburayalu J, Kaplan MJ, Summers C, Guck J, Chilvers ER, Toepfner N. Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming. J Leukoc Biol 2019; 105:1143-1153.
Vogt KL, Summers C, Condliffe AM. The clinical consequences of neutrophil priming. Curr Opin Hematol 2019; 26:22-27.
Shakar Hari M, Summers C. Major surgery and the immune system: from pathophysiology to treatment. Curr Opin Crit Care 2019; 24:588-593.
Farahi N, Loutsios C, Tregay N, Wright AKA, Berair R, Lok LSC, Gillett D, Cullum I, Simmonds RP, Summers C, et al. In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients. J Allergy Clinic Immunol2018; 142:1659-1662.
Proudfoot AG, O’Kane CM, Bayliffe A, Serone A, Bareille PJ, Smith S, Brown V, Hamid UI, Wright T, Chen Y, Wilson R, Cordy J, van Wilte R, Morley P, Elborn JS, Hind M, Chilvers ER, Griffiths M, Summers C*, McAuley DF*. A domain antibody to the tumour necrosis factor receptor one (TNFR1) prevents pulmonary inflammation in experimental models of acute respiratory distress syndrome. Thorax 2018, in press. (*joint senior authors).
Lambden S, Creagh-Brown BC, Hunt J, Summers C, Forni L. Definitions and pathophysiology of vasoplegic shock. Critical Care 2018; 22:174.
Vogt KL, Summers C, Chilvers ER, Condliffe AM. Priming and de-priming of neutrophil responses in vitro and in vivo. Eur J Clin Invest 2018; 48:e12967.
Griffiths SV, Conway DH; POPC-CB Investigators, Sander M, Jammer I, Grocott MPW, Creagh-Brown BC. What are the optimum components in a care bundle aimed at reducing post-operative pulmonary complications in high-risk patients? Perioper Med (Lond) 2018; 7:7.
Cowburn AS, Macias D, Summers C, Chilvers ER, Johnson RS. Cardiovascular adaptation to hypoxia and the role of peripheral resistance. eLife, 2017, in press.
Ekpenyong AE, Töpfner N, Fiddler C, Herbig M, Li W, Cojoc G, Summers C, Guck J, Chilvers ER. Mechanical deformation induces depolarisation of neutrophils. Science Advances 2017; 3:e1602536.
Desautels T, Das R, Calvert J, Trivedi M, Summers C, Wales D, Ercole A. Prediction of early unplanned intensive care unit readmission in a UK tertiary-care hospital: A cross-sectional machine learning approach. BMJ Open 2017, in press.
Summers C, Singh NR, Worpole L, Simmonds R, Babar J, Condliffe AM, Gunning KE, Johnston AJ, Chilvers ER. Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit. Thorax 2016; 71:1050-1051.
Juss JK, House D, Amour A, Begg M, Herre J Storisteanu DML, Hoenderdos K, Bradley G, Lennon M, Summers C, Hessel EM, Condliffe AM and Chilvers ER. ARDS neutrophils have a distinct phenotype and are resistant to phophoinositide 3-kinase inhibition. Am J Respir Crit Care Med 2016; 194:961-973.
Hoenderdos K, Lodge K, Hirst RA, Chen C, Palazzo SGC, , Emerenciana A, Summers C, Angyal A, Porter L, Juss JK, O’Callaghan C, Chilvers ER, Condliffe AM. Hypoxia up-regulates neutrophil degranulation and potential for tissue injury. Thorax 2016; 71:1030-1038.
Millar FR, Summers C, Griffiths MJ, Toshner MR, Proudfoot AG. The pulmonary endothelium in the Acute Respiratory Distress Syndrome – insights and therapeutic opportunities. Thorax 2016; 71:462-473.
Summers C, Singh NR, White JF, Mackenzie IM, Johnston A, Solanki C, Balan KK, Peters AM, Chilvers ER. Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in acute respiratory distress syndrome. Thorax 2014; 69:623-629.
Summers C, Chilvers ER, Peters AM. Mathematical modelling supports the presence of neutrophil de-priming in vivo. Physiological Reports 2014; 2:e00241.
Proudfoot AG and Summers C. Killing without collateral damage: A new hope for sepsis therapy. Immunol Cell Biol2014; 94:739-40.
Farahi N, Singh NR, Heard S, Loutsios C, Summers C, Simmonds RP, Solanki CK, Solanki K, Balan KK, Ruparelia P, Peters AM, Condliffe AM, Chilvers ER. Use of 111-Indium-labelled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects. Blood 2012; 120: 4068-4071.
Singh N, Johnston A, Peters AM, Babar J, Chilvers ER, Summers C. Acute lung injury results from failure of neutrophil de-priming: a new hypothesis. Eur J Clin Invest 2012; 42: 1342-1349.
McGovern NN, Cowburn AS, Porter L, Walmsley SR, Thompson AA, Summers C, Willcocks LC, Whyte MKB, Condliffe AM, Chilvers ER. Hypoxia inhibits respiratory burst activity and killing of staphylococcus aureus in human neutrophils. J Immunol 2011; 186: 453-463.
Szczepura KR, Ruparelia P, Solanki CK, Balan KK, Newbold P, Summers C, Chilvers ER, Peters AM. Measuring whole-body neutrophil redistribution using a dedicated whole body counter and ultra-low doses of 111Indium (whole body counting). Eur J Clin Invest 2011; 41: 77-83.
Cowburn AS, Summers C, Dunmore BJ, Farahi N, Hayhoe RP, Print CG, Cook SJ, Chilvers ER. GM-CSF causes a paradoxical increase in the BH3-only protein Bim in human neutrophils. Am J Respir Cell Mol Biol 2011; 44: 879-887.
White JF, Cowburn AS, Summers C, Cadwallader KA, Mackenzie I, Prasaedom RJ, Peters AM, Chilvers ER. The influence of the spleen on neutrophil apoptosis in vivo. J Cell Death 2011; 4: 1-5.
Ruparelia P, Szczepura K, Summers C, Solanki CK, Balan KK, Newbold P, Bilton D, Peters AM, Chilvers ER. Quantification of 111In-neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease. Eur J Nucl Med Mol Imaging 2011; 38: 911-919.
Summers C, Rankin SM, Condliffe AM, N Singh, Peters AM, ER Chilvers. Neutrophil kinetics in health and disease. Trends Immunol 2010; 31:318-324.
Ruparelia P, Szczepura K, Summers C, Peters AM, Chilvers ER. 99mTechnetium-labelled neutrophil scanning in pneumonia. Thorax 2009; 64:92.
Gooptu B, Miranda E, Nobeli I, Mallya M, Purkiss A, Leigh-Brown SC, Summers C, Phillips RL, Lomas DA, Barrett TE. Crystallographic and cellular characterisation of two mutations stabilising the native fold of alpha1-antitrypsin: implications for rational drug design. J Mol Biol 2009; 387:857-68.
Cowburn AS, Condliffe AM, Farahi N, Summers C, Chilvers ER. Advances in neutrophil biology: clinical implications. Chest 2008; 134: 606-612.
Durrington HJ, Summers C. Recent changes in the management of community acquired pneumonia. BMJ 2008; 336:1429-1433.
Enoch DA, Summers C, Brown NM, Moore L, Gillham MI, Burnstein RM, Thaxter R, Enoch LM, Matta B, Sule O. Investigation and management of an outbreak of multidrug-carbapenem-resistant Acinetobacter baumannii in Cambridge, UK. J Hosp Infect 2008; 70:109-118.
Lambden SPF and Summers C. Biomarkers in critical illness: ARDS and sepsis. In Precision in pulmonary, critical care and sleep medicine. Eds: Gomez JL, Himes BE, Kaminski N. Springer International Publishing, New York, 2020.
Shankar-Hari M, Summers C, Baillie K. In pursuit of precision medicine in the critically ill. In Annual Update in intensive Care Medicine 2018. Ed: Vincent J-L. Springer International Publishing, Switzerland, 2018.
Lambden SL and Summers C. Bridging the translational gap: The challenges of novel drug development in Critical Care. In Annual Update in Intensive Care and Emergency Medicine 2017. Ed: Vincent J-L. Springer International Publishing, Switzerland.
Proudfoot AG and Summers C. Respiratory disorders: ARDS in Cardiothoracic ICU. In Core Topics in Cardiothoracic Critical Care 2nd edition. Eds: Valchanov K, Jones, N, Hogue, C. Cambridge University Press, UK, in press.
Summers C and Belligan G. Therapeutic strategy for acute respiratory distress syndrome (ARDS). In: Oxford Textbook of Critical Care Medicine 2nd edition. Eds: Webb A, Angus D, Finfer S, Gattinoni L, Singer M. Oxford University Press, 2016.
Loutsios C, Farahi N, Summers C, Ruparelia P, White JF, Potts J, Solanki CK, Solanki K, Heard S, Gillett D, Balan KK, Condliffe AM, Peters AM, Chilvers ER. Use of Radiolabelled Leukocytes for Drug Evaluation in Man. In: Pharmaco-Imaging in Drug and Biologics Development: Fundamentals and Applications. Eds: Moyer BR, Chevuvu, Hu TCC. Springer, New York, 2014.